First prophylaxis treatment in a prefilled, subcutaneous pen to prevent or reduce the frequency of bleeding episodes in adults and children 12 years of age and older with hemophilia B with inhibitors or hemophilia A with inhibitors. It is not known if Alhemo® is safe and effective in people receiving ongoing immune tolerance induction (ITI) or in children younger than 12 years of age.
aIt is important to follow the daily dosing schedule of Alhemo® to stay protected against bleeding.
Royal lives with hemophilia B with inhibitors, uses Alhemo®, and is an employee of Novo Nordisk.
Needles provided separately and may require a prescription in some states.
Alhemo® is a prescription medicine used for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and children 12 years of age and older with hemophilia B with Factor 9 inhibitors or hemophilia A with Factor 8 inhibitors.
Everyday bleed protection in a pen designed with you in minda
Most common adverse reactions with Alhemo®: Injection site reactions (18%) and urticaria (6%).
320 males with hemophilia A with and without inhibitors and hemophilia B with and without inhibitors received at least 1 dose of Alhemo® as routine prophylaxis. 52 people with inhibitors were previously treated with on-demand therapy and were randomized to receive on-demand treatment with bypassing agents (19 people) or Alhemo® prophylaxis (33 people).
Royal lives with hemophilia B with inhibitors, uses Alhemo®, and is an employee of Novo Nordisk.
Clinical study of Alhemo® included people ages 12 and older who had hemophilia B with inhibitors (53 people) and hemophilia A with inhibitors (80 people) who were treated with or are in need of either bypassing agents on demand (at least 24 weeks) or Alhemo® once-daily prophylaxis (at least 32 weeks). 86% annual bleed rate (ABR) reduction with Alhemo® (33 people) compared with on-demand bypassing agents (19 people). The mean ABR was 1.7 for people treated with Alhemo® and 11.8 for people treated with on-demand bypassing agents. The median ABR was 0 for patients on Alhemo® and 9.8 for patients on no prophylaxis.
aIt is important to follow the daily dosing schedule of Alhemo® to stay protected against bleeding.
bStore in refrigerator before first use. After first use, Alhemo® can be stored at room temperature below 86 ℉ (30 ℃) or in a refrigerator at 36 ℉ to 46 ℉ (2 ℃ to 8 ℃) for up to 4 weeks.
cRead the Instructions for Use for information about how to prepare and inject Alhemo®, and how to properly throw away used pens and needles. Your healthcare provider should show you or your caregiver how to use Alhemo® before you use it for the first time.
dFor a person who weighs 70 kg (154 lb) on a daily dose of 0.2 mg/kg and using the (gold label) 150 mg/1.5 mL pen, the volume to inject is 0.14 mL per dose.
eCarefully follow your healthcare provider’s instructions regarding when to use on-demand BPAs and the recommended dose and schedule for breakthrough bleeds.
Life with hemophilia with inhibitors, in their words
Meet members of the community and hear how they navigate life, care, and advocacy.
Jericho lives with hemophilia A with inhibitors and uses Alhemo®. Royal lives with hemophilia B with inhibitors, uses Alhemo®, and is an employee of Novo Nordisk.
See the science behind Alhemo®
Alhemo® works by blocking a protein called TFPI, which naturally prevents clotting. By blocking TFPI, Alhemo® helps your blood clot when you’re missing factors 8 or 9 and have inhibitors.
Powerful bleed protection
Proven to prevent bleeds. Learn more about how Alhemo® works to reduce bleeds.
Subcutaneous administration with a prefilled pen
Administration designed to fit your lifestyle.
Life with a bleeding disorder can come with challenges—and questions. That’s why Novo Nordisk offers more than treatment. Our Rare Blood Community Liaisons (RBCLs) provide one-on-one support, including:
Brittany (left) and Stacey (right) are Novo Nordisk RBCLs.
Want to learn more about Alhemo®? Get important email updates, information about patient support programs, and more.